WHAT IS COLD-FX®?
COLD-FX® is a natural cold remedy brand with a clinically proven formula that contains the active ingredient CVT-E002®, which is naturally sourced by a proprietary technology to ensure the quality and consistency of every capsule.
It helps to reduce the frequency, severity and duration of cold and flu symptoms by boosting the immune system.
It is the only cold and flu brand on the Canadian market to contain the active ingredient CVT-E002®.
CVT-E002® is a standardized extract from the root of North American ginseng, specifically derived through a patented technology.
Each batch of CVT-E002® is tested with, ChemBioPrint®technology a patented process that ensures consistency of our products from batch to batch.”A Proven Solution”
COLD-FX®, COLD-FX® Chewable and COLD-FX® EXTRA are formulated to help reduce the frequency, severity and duration of cold and flu symptoms by boosting the immune system.
THE SCIENCE BEHIND COLD-FX®
The science of COLD-FX® is backed by:
COLD-FX® IS THE ONLY COLD AND FLU BRAND ON THE CANADIAN MARKET
TO CONTAIN THE ACTIVE INGREDIENT CVT-E002®.
HOW COLD-FX® WORKS
COLD-FX® active ingredient, CVT-E002®, helps reduce the frequency, severity and duration of cold and flu symptoms by boosting the immune system.
Your immune system
Our immune system protects us from any foreign organisms such as viruses, bacteria, and more. The immune system has two major parts:
1. Innate: The innate part of our immune system is the non-specific, first line of defense against infections. The innate immune response works within minutes to hours of infection.
2. Adaptive: The adaptive portion of our immune system is the “trained” part. When our body is exposed to a virus or bacteria, it remembers the encounter and develops specific cells and molecules that will rapidly fight off the same foreign agents when we encounter them again. This is also how vaccinations work.
- How does COLD-FX® boost your immune system?
CVT-E002®, the active ingredient in COLD-FX®, has been demonstrated in clinical studies to increase the proportion of natural killer cells and T-helper cells.These cells play an important role in both the innate and adaptive immune response.
Natural killer (NK) cells play a major role in the innate immune response. These cells identify host cells that have been infected by a foreign organism (virus, bacteria, etc.) and attempt to destroy them. For example, when a cell is infected by a flu virus, NK cells will recognize the cell that has been compromised and initiate the destruction of this “rogue” cell.
T-helper cells (T-cells) are one of the most important cells in the adaptive immune response. These cells are crucial in achieving a regulated and effective immune response to foreign organisms or infected host cells.
This however, does not mean COLD-FX® needs to be taken for eight weeks to six months to experience benefits.
For instance, a study with professional hockey players showed that taking COLD-FX® (400 mg/day) for 30 days enhanced immune response of peripheral blood lymphocytes (cells of our immune system, which include T-cells, Natural Killer (NK) cells and B-cells) to influenza viruses, indicating an immune boosting effect as early as 30 days.
The following clinical trials have shown the safety and efficacy of COLD-FX® in a broad range of patient groups:
- Pivotal COLD-FX® Trial in Healthy Adults (18-65 years)Predy et al. 2005
- Pivotal COLD-FX® Trial in Healthy SeniorsMcElhaney et al. 2004
- Pivotal COLD-FX® Trial in Nursing Home SeniorsMcElhaney et al. 2006
- COLD-FX® Trial in Community-Dwelling SeniorsMcElhaney et al. 2011
- Pilot COLD-FX® Trial in High Performance AthletesMcElhaney et al. 2010
- COLD-FX® Doping Control Urinalysis Trial in AthletesGoel et al. 2004
- COLD-FX® Safety in Children (Acute Dosing)Vohra et al. 2008
- COLD-FX® Safety and Efficacy in Immune-Compromised PatientsHigh et al. 2012
Predy GN, Goel V, Lovlin RE et al . Immune modulating effects of daily supplementation of COLD-FX (a proprietary extract of North American ginseng) in healthy adults. J Clin Biochem Nutr 2006;39:162-7.
McElhaney JE, Gravenstein S, Cole SK et al. A Placebo-Controlled Trial of a Proprietary Extract of North American Ginseng (CVT-E002) to Prevent Acute Respiratory Illness in Instituionalized Older Adults. J Am Geriatr Soc 2004;52:13-9.
 Predy GN, Goel V, Lovlin RE et al. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. Can Med Assoc J. 2005;173(9): 1043-8.
 McElhaney JE, Simor AE, McNeil S et al. Efficacy and safety of CVT-E002®, a proprietary extract of Panax quinquefolius in the prevention of respiratory infections in influenza-vaccinated community-dwelling adults: a multicenter, randomized, double-blind and placebo-controlled trial. Influenza Res Treat 2011;2011:1-8.
McElhaney JE, Guilbert LJ, Reid D et al. COLD-FX stimulates cell mediated immune response of peripheral leukocytes ex-vivo to influenza virus in national hockey league players.The Open Nutraceuticals Journal. 2010: (3)25-29.
THE FLU SHOT WORK?
The seasonal flu vaccine protects against the flu by stimulating our immune system to produce specific molecules, called antibodies, which provide protection against infection. Each year the flu vaccine is created with the influenza virus strains that research indicates will be the most common strain during the upcoming season.
The effectiveness of the flu shot is dependent on the successful prediction of the influenza strain that will be active that year. Recent studies from the U.S. show vaccine reduces the risk of flu illness by about 50% to 60% when most circulating flu viruses are similar to those included in the vaccine.
However, this effectiveness may vary from year to year. For example, according to the Center for Disease Control and Prevention in the United States, the 2014-2015 flu shot was about 19% effective in preventing medical visits against all influenza across all age groups.
COMPLIMENTS THE FLU SHOT
 Flu.gov. “How The Flu virus Changes.” Retrieved from: http://www.flu.gov/about_the_flu/virus_changes/ . Accessed on February 9, 2016.
 Canadian Center for Occupational Health and Safety. “Common Cold.” Retrieved from: https://www.ccohs.ca/oshanswers/diseases/common_cold.html . Assessed February 9, 2016.
 Centers For Disease Control and Prevention. Retrieved from: http://www.cdc.gov/flu/about/qa/vaccineeffect.htm . Accessed February 8, 2016.
 Centers For Disease Control and Prevention. Retrieved from: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6421a5.htm . Accessed February 8, 2016.
 Centers For Disease Control and Prevention. Retrieved from: http://www.cdc.gov/flu/protect/keyfacts.htm . Accessed February 19, 2016.
 McElhaney JE, Simor AE, McNeil S et al. Efficacy and safety of CVT-E002 ® , a proprietary extract of panax quinquefolius in the prevention of respiratory infections in influenza-vaccinated community-dwelling adults: a multicenter, randomized, double-blind and placebo-controlled trial. Influenza Res Treat 2011;2011:1-8.
WHAT MAKES COLD-FX®
COLD-FX® helps reduce the frequency, severity and duration of cold and flu symptoms by boosting the immune system. CVT-E002® is the clinically proven medicinal ingredient in COLD-FX®. It is obtained using a proprietary and standardized extraction technology. Every lot of CVT-E002® is tested using ChemBioPrint® (Chemical and Biological Finger Printing) technology.
ChemBioPrint® was developed with the contribution of a world class team of scientists and international academic and research collaborators, to ensure consistent chemical identity and biological activity of herbal extracts and therefore, consistency and quality of the COLD-FX® products.
Every lot of CVT-E002® is rigorously tested before encapsulation. Its biological activity is confirmed with proprietary ChemBioPrint® technology to measure its effect of the number of lymphocytes (immune system cells) using specially designed tests.
HOW MUCH COLD-FX®
SHOULD I TAKE AND WHEN?
To be sure these products are right for you, always read and follow your COLD-FX® product label.
It contains important information on dosing, recommended use, cautions, warnings and contraindications.
Adults: Take 1-2 capsules 2 times daily, up to 9 capsules/chewable tablets per day.
Children 12 years of age and older: Take 1 capsule 2 times daily.
Adults: Take 1 capsule 2 times daily, up to 6 capsules per day.
- NPN 80002849, 80069106
- NPN 80015586